Cognitive Peptides

Selank (TP-7)

Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, developed at the Russian Academy of Sciences. It is approved in Russia as a prescription treatment for generalized anxiety disorder and asthenic conditions. Research has focused on its effects on GABA receptor modulation, serotonin metabolism, BDNF expression, and immune signaling through its tuftsin-derived structure. Research dosing is typically 200–500mcg twice daily via intranasal spray or subcutaneous injection in 2–4 week cycles. Researchers monitor cortisol, BDNF (when available), and subjective stress and anxiety scores as the primary response markers.

Semax (ACTH 4-7 analog)

Semax is a synthetic heptapeptide analog of ACTH (4-7) developed at Moscow State University in the late 1980s. It is approved in Russia for ischemic stroke recovery, cognitive impairment, and neurological rehabilitation, and research has focused on its effects on BDNF, NGF, monoamine neurotransmitter systems, and melanocortin receptor activation. Unlike stimulants, Semax does not directly affect dopamine or norepinephrine release. Research dosing is 300–900mcg twice daily via intranasal spray in short 2–4 week cycles. BDNF, cortisol, and ACTH are the biomarkers researchers most often track, alongside validated cognitive performance scales.

N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide

Dihexa is a synthetic oligopeptide derivative of angiotensin IV that has been called 'ten million times more potent than BDNF' for its ability to promote new synaptic connections. It is studied for cognitive enhancement and neurodegenerative conditions including Alzheimer's disease.

FPF-1070

Cerebrolysin is a porcine brain-derived peptide complex containing low-molecular-weight neuropeptides and free amino acids. It is approved in several countries for stroke recovery, traumatic brain injury, and dementia, but is not FDA-approved in the United States.

HN

Humanin is a mitochondrial-derived peptide encoded within the 16S ribosomal RNA gene. It was discovered through its ability to protect neurons from Alzheimer's disease-related toxicity and is studied for neuroprotection, metabolic regulation, and anti-aging applications.

EDR

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) from the Khavinson bioregulator series, studied for its potential role in regulating pineal gland function and neuroprotective signaling pathways in preclinical models.

Semax/Selank

Pre-mixed blend of Semax (BDNF-promoting nootropic) and Selank (anxiolytic tuftsin analog). Combines neurotrophic support with anxiolytic GABA modulation in a single preparation.