Pinealon

Overview

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) from the Khavinson bioregulator series, studied for its potential role in regulating pineal gland function and neuroprotective signaling pathways in preclinical models.

Mechanism of Action

Pinealon is theorized to act as a gene-regulatory peptide that penetrates cell membranes and interacts with DNA, modulating transcription of genes involved in pineal gland melatonin synthesis and neuronal survival. In vitro studies suggest it upregulates expression of genes associated with antioxidant defense and anti-apoptotic signaling in neuronal cell cultures.

Research Summary

Khavinson et al. (Rejuvenation Research, 2011, PMID 21978084) reported that Pinealon suppressed reactive oxygen species accumulation, reduced cell death, and modulated cell-cycle progression across multiple cell types under oxidative stress, with the authors suggesting direct genome-level interaction. Arutjunyan et al. (International Journal of Clinical and Experimental Medicine, 2012, PMID 22567179) reported that Pinealon administered to pregnant rats on a methionine (hyperhomocysteinemia) diet improved spatial learning and reduced ROS accumulation in cerebellar neurons of offspring. The evidence base is dominated by Khavinson's St. Petersburg Institute of Bioregulation and Gerontology and has not been independently replicated in Western clinical trials. No Phase II or III trials exist; Pinealon is not FDA-approved.

Vendors selling Pinealon

Scored vendors carrying Pinealon, ranked by trust grade. Grades are computed from indexed Certificates of Analysis. Full $/mg pricing is on the comparison page.

Prescribers who offer Pinealon

12 prescribers in our directory work with Pinealon, each confirmed from their own website. Peptides like Pinealon require a prescription from a licensed provider — telehealth options are available.

Reported Side Effects

• Limited human safety data
• Mild headache reported anecdotally
• Drowsiness or sedation at higher doses
• Injection site irritation (subcutaneous use)

Compare Pinealon with Others

Research References

• Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes (2011)
• Pinealon protects the rat offspring from prenatal hyperhomocysteinemia (2012)

Frequently asked questions

Has Pinealon been independently lab-tested?

Disclosed Labs has collected 32 Certificates of Analysis (COA) for Pinealon from 9 independent testing labs. 15 vendors have submitted material for testing. Products average 98.7% tested purity across the corpus. Full testing data is available at https://www.disclosedlabs.com/peptides/pinealon/testing.

What is the average purity of Pinealon on the market?

Based on 32 COAs analyzed by Disclosed Labs, Pinealon products average 98.7% (±4.3%) tested purity. Individual vendor results vary; see per-vendor COA data at https://www.disclosedlabs.com/peptides/pinealon/coas.

Which labs have tested Pinealon?

Independent labs that have tested Pinealon include: ILS Labs (Grade A). Full lab credibility grades and profiles are at https://www.disclosedlabs.com/labs.

Where can researchers source Pinealon?

8 vendors with Disclosed Labs trust grades currently list Pinealon, including OROS Research, Peptide Plugs, Skye Peptides. Compare live prices and lab-verified COAs at https://www.disclosedlabs.com/prices/pinealon.

Which prescribers offer Pinealon with a prescription?

12 prescribers in the Disclosed Labs directory work with Pinealon, each confirmed from their own website, with telehealth options available. Pinealon requires a prescription from a licensed provider. Browse them at https://www.disclosedlabs.com/prescribers?peptide=Pinealon.

How does Pinealon work?

Pinealon is theorized to act as a gene-regulatory peptide that penetrates cell membranes and interacts with DNA, modulating transcription of genes involved in pineal gland melatonin synthesis and neuronal survival. In vitro studies suggest it upregulates expression of genes associated with antioxidant defense and anti-apoptotic signaling in neuronal cell cultures.

What does the research say about Pinealon?

Khavinson et al. (Rejuvenation Research, 2011, PMID 21978084) reported that Pinealon suppressed reactive oxygen species accumulation, reduced cell death, and modulated cell-cycle progression across multiple cell types under oxidative stress, with the authors suggesting direct genome-level interaction. Arutjunyan et al. (International Journal of Clinical and Experimental Medicine, 2012, PMID 22567179) reported that Pinealon administered to pregnant rats on a methionine (hyperhomocysteinemia) diet improved spatial learning and reduced ROS accumulation in cerebellar neurons of offspring. The evidence base is dominated by Khavinson's St. Petersburg Institute of Bioregulation and Gerontology and has not been independently replicated in Western clinical trials. No Phase II or III trials exist; Pinealon is not FDA-approved.