Dihexa

Overview

Dihexa is a synthetic oligopeptide derivative of angiotensin IV that has been called 'ten million times more potent than BDNF' for its ability to promote new synaptic connections. It is studied for cognitive enhancement and neurodegenerative conditions including Alzheimer's disease.

Mechanism of Action

Dihexa acts as a hepatocyte growth factor (HGF) receptor (c-Met) agonist, promoting dendritic spine formation and new synaptic connections in the brain. It crosses the blood-brain barrier and enhances neuronal connectivity through the HGF/c-Met signaling pathway, which is critical for neurogenesis and synaptic plasticity.

Research Summary

Preclinical studies at Washington State University demonstrated that dihexa reversed cognitive deficits in scopolamine-treated rats and improved memory in aged animals. It promotes synaptogenesis at extremely low concentrations. No human clinical trials have been conducted, and long-term safety data is absent.

Dosing Information

Reported Side Effects

• Headache
• Elevated blood pressure (angiotensin pathway)
• Anxiety or overstimulation
• Unknown long-term effects

Research References

• Dihexa, a HGF/c-Met receptor agonist, rescues cognitive decline in models of Alzheimer's disease (2013)
• Hepatocyte growth factor/c-Met signaling in the brain: role in neuroprotection (2014)
• An angiotensin IV analog enhances cognitive function in rodent models (2004)