CognitiveResearch Only

P21

CNTF-peptide

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Reconstitution

Overview

P21 is a small peptidomimetic derived from a CNTF (ciliary neurotrophic factor) region. Studied for neurogenesis and Alzheimer's-related cognitive decline.

Mechanism of Action

Stimulates neurogenesis via CNTF-pathway activation, promotes BDNF expression, and may reduce tau pathology in preclinical AD models.

Research Summary

Preclinical rodent studies in Alzheimer's and aging-related cognitive decline. No human trials.

Dosing Information

Typical Dose

0.5–1 mg

Frequency

Daily

Route

Intranasal or SubQ

Notes

Research-only; pharmacokinetics poorly characterized in humans.

Reported Side Effects

Headache
Mild irritation at delivery site

Contraindications

Pregnancy
Known hypersensitivity

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