PE-22-28

Overview

PE-22-28 is a synthetic peptide fragment derived from proenkephalin that has shown promising results for promoting hair growth. It is studied for its ability to stimulate the dermal papilla cells and extend the anagen (growth) phase of the hair cycle.

Mechanism of Action

PE-22-28 activates the Wnt/β-catenin signaling pathway in dermal papilla cells, which is essential for hair follicle development and cycling. It also promotes proliferation of hair matrix keratinocytes and increases the expression of growth factors (VEGF, KGF) in the hair follicle microenvironment.

Research Summary

In vitro studies demonstrate enhanced proliferation of dermal papilla cells and upregulation of hair growth-associated genes. Animal studies in mice showed increased hair density and prolonged anagen phase. Human clinical data is extremely limited, and efficacy has not been established in controlled trials.

Dosing Information

Reported Side Effects

• Scalp irritation (topical)
• Injection site discomfort (SubQ)
• Headache
• Unwanted facial hair growth (if applied broadly)

Research References

• Proenkephalin-derived peptide PE-22-28 enhances hair growth through Wnt/β-catenin activation (2018)
• Wnt/β-catenin signaling in dermal papilla cells and hair follicle biology (2012)
• Growth factor signaling in hair follicle development and cycling (2007)