Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
A 7-amino-acid synthetic analog of spadin that selectively blocks the TREK-1 two-pore potassium channel; studied preclinically as a fast-acting antidepressant. Not a hair-growth peptide.
Lowest Price
$44.99
Highest Price
$540.00
Average Price
$95.00
Potential Savings
65%
across 11 options
1 of 11 vendors are lab-verified for PE-22-28
We cross-check each vendor's Certificate of Analysis against the issuing lab's own verification portal — so “cheapest” isn't the only signal.
Best price trend
Lowest $/mg for PE-22-28 · last 45 days
$3.46/mg
▼ 31% vs 45d ago
Trust grade first, cheapest within grade
vial · 10mgionpeptide.com· price updated today
Lot PE228-05202026· tested 2026-05-29
$4.90/mg
29% more per mg
vial · 10mgpeptidology.co· price updated today
Lot 1666· tested 2025-11-18
$5.00/mg
31% more per mg
vial · 13mgpolarispeptides.com· price updated today
$3.46/mg
vial · 10mgmodernresearchpeptides.net· price updated today
$4.50/mg
23% more per mg
vial · 10mgpeptira.com· price updated today
$4.90/mg
29% more per mg
vial · 8mgamc-essentials.com· price updated today
$6.00/mg
42% more per mg
vial · 8mgcorepeptides.com· price updated today
$6.75/mg
49% more per mg
vial · 80mgatomiklabz.com· price updated today
$6.75/mg
49% more per mg
vial · 8mgbiotechpeptides.com· price updated today
$6.88/mg
50% more per mg
vial · 8mgsolutionpeptides.net· price updated today
$7.50/mg
54% more per mg
vial · 5mgwellilabs.com· price updated 2d ago
$10.00/mg
65% more per mg
vial · 10mgpeptidetech.co· price updated 2d ago
$5.00/mg
31% more per mg
Check formulation: Lyophilized powder requires reconstitution before use. Pre-mixed solutions are more convenient but may have a shorter shelf life and higher prices.
Compare per-mg cost: Different strengths and quantities make direct price comparison difficult. Calculate the per-milligram cost to find the true best value.
Verify COAs: Look for vendors that publish per-batch Certificates of Analysis from named, accredited labs. Every vendor on this page is verified for endotoxin testing — not just HPLC purity.
Mazella, Borsotto and colleagues at Nice, France identified spadin (Mazella et al., PLoS Biology 2010, PMID 20405001) and subsequently developed shortened PE 22-28 analogs with ~300× improved TREK-1 affinity and longer in vivo half-life (Djillani et al., Front Pharmacol 2017, PMID 28955242). In mouse antidepressant assays (forced swim, tail suspension, novelty-suppressed feeding), acute or 4-day IP dosing at ~3–4 μg/kg produced effects comparable to chronic SSRI treatment; oral gavage at 1 mg/kg was also active. The G/A-PE 22-28 modification extended duration of action to ~21–23 hours. Chronic dosing did not produce cardiac or seizure signals in rodents. No human clinical trials have been conducted. A detailed review of TREK-1 blockers for depression is available in Djillani et al., Pharmacol Ther 2019 (PMID 30291907).
This platform provides informational tools only, not medical advice.
Shortened spadin analogs display better TREK-1 inhibition, in vivo stability, and antidepressant activity
2017
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design
2010
Fighting against depression with TREK-1 blockers: past and future. A focus on spadin
Prices verified as of June 2026. Actual prices may vary. For research use only.
Prices are estimates and may vary. For research use only. We may earn a commission on purchases through affiliate links. Not medical advice.
2019
Disclosed Labs