Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
A 7-amino-acid synthetic analog of spadin that selectively blocks the TREK-1 two-pore potassium channel; studied preclinically as a fast-acting antidepressant. Not a hair-growth peptide.
0 of 4 vendors lab-verified
Verified purity per dollar — the cheapest that's actually been tested
vial · 10mg· ionpeptide.com· price updated today
$49.00✓ $4.90/mg
single-vial price — packs may be lower
vial · 10mg· peptidology.co· price updated today
$49.99✓ $5.00/mg
2% more per mg vs cheapest
single-vial price — packs may be lower
vial · 8mg· realpeptides.co· price updated today
$55.00✓ $6.88/mg
29% more per mg vs cheapest
single-vial price — packs may be lower
vial · 10mg· simplepeptide.com· price updated today
$72.00✓ $7.20/mg
32% more per mg vs cheapest
single-vial price — packs may be lower
vial · 10mg· peptidetech.is· price updated today
$49.99$5.00/mg
single-vial price — packs may be lower
9 vendors not shown — trust grade below C, or not enough verified COA data yet. We only list sources with a C grade or better.
Best price trend
Lowest $/mg for PE-22-28 · verified listings only
$4.00/mg
▼ 20% over 90d
Ion Peptide has the lowest single-vial PE-22-28 price at $4.90/mg among 5 COA-verified vendors on Disclosed Labs. Bulk or multi-vial deals may be lower. That's 32% less per mg than the most expensive option.
What is the price range for PE-22-28?
Research-grade PE-22-28 ranges from $4.90/mg to $7.20/mg across 5 verified sources, a 32% spread per mg.
How are PE-22-28 prices verified on Disclosed Labs?
Every listed vendor holds a Grade C or better trust score, computed independently from lab Certificates of Analysis — not from payments or sponsorships. Prices are scraped and fact-checked daily. Vendors cannot pay to improve their ranking.
Check formulation: Lyophilized powder requires reconstitution before use. Pre-mixed solutions are more convenient but may have a shorter shelf life and higher prices.
Compare per-mg cost: Different strengths and quantities make direct price comparison difficult. Calculate the per-milligram cost to find the true best value.
Verify COAs: Look for vendors that publish per-batch Certificates of Analysis from named, accredited labs. Use the Full safety panel filter to require endotoxin, sterility, and heavy-metals testing on the current batch — not just HPLC purity.
Mazella, Borsotto and colleagues at Nice, France identified spadin (Mazella et al., PLoS Biology 2010, PMID 20405001) and subsequently developed shortened PE 22-28 analogs with ~300× improved TREK-1 affinity and longer in vivo half-life (Djillani et al., Front Pharmacol 2017, PMID 28955242). In mouse antidepressant assays (forced swim, tail suspension, novelty-suppressed feeding), acute or 4-day IP dosing at ~3–4 μg/kg produced effects comparable to chronic SSRI treatment; oral gavage at 1 mg/kg was also active. The G/A-PE 22-28 modification extended duration of action to ~21–23 hours. Chronic dosing did not produce cardiac or seizure signals in rodents. No human clinical trials have been conducted. A detailed review of TREK-1 blockers for depression is available in Djillani et al., Pharmacol Ther 2019 (PMID 30291907).
This platform provides informational tools only, not medical advice.
Shortened spadin analogs display better TREK-1 inhibition, in vivo stability, and antidepressant activity
2017
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design
2010
Fighting against depression with TREK-1 blockers: past and future. A focus on spadin
Prices verified as of July 2026. Actual prices may vary. For research use only.
Single-vial list prices by default for a fair head-to-head — switch to Multi-vial / bulk for pack pricing. Estimates only; verify at vendor before purchase. For research use only. Not medical advice.
2019
Disclosed Labs