Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Tropisetron is a non-peptide small-molecule indole-tropane carboxylate ester with dual receptor activity: competitive antagonism at 5-HT3 serotonin receptors and partial agonism at α7 nicotinic acetylcholine receptors. Approved in 1992 as a prescription antiemetic (marketed as Navoban outside the United States) for chemotherapy- and radiotherapy-induced nausea and vomiting, it is NOT approved or marketed in the US. Beyond its approved indication, tropisetron has registered human RCT data in fibromyalgia and schizophrenia-associated cognitive deficits; NO validated human dosing exists for cognitive enhancement in healthy individuals. Available from gray-market research-chemical vendors labeled for laboratory research only.
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Kimera Chems has the lowest single-vial Tropisetron price at $0.052/mg among 3 COA-verified vendors on Disclosed Labs. Bulk or multi-vial deals may be lower.
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Research-grade Tropisetron is listed at $0.052/mg from 1 verified source on Disclosed Labs.
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Tropisetron is an approved prescription drug for chemotherapy-/radiotherapy-induced nausea and vomiting. Human RCT data exist for two investigational uses: (a) a randomized, double-blind, placebo-controlled multicenter trial in 418 fibromyalgia patients (5/10/15 mg once daily × 10 days) reported a higher responder rate in the 5 mg arm than placebo; and (b) an 8-week randomized, double-blind, placebo-controlled trial in 40 risperidone-treated schizophrenia patients (10 mg/day add-on) improved P50 auditory gating and sustained visual attention versus placebo. NO validated human dosing exists for cognitive enhancement in healthy individuals. Preclinical findings include: in vitro (Xenopus oocytes) confirmation of α7-selective partial agonism; in vivo (young/aged rats, aged rhesus monkeys) improvements in novel-object-recognition and delayed-match-to-sample accuracy with systemic tropisetron; rat 3-nitropropionic-acid Huntington's model showing improved motor/behavioral deficits and modulation of Nrf2/HO-1, PI3K/Akt, and JAK2/NF-κB signaling; and rat pilocarpine temporal-lobe-epilepsy model demonstrating reduced spontaneous seizures and hippocampal sclerosis via an α7nAChR-dependent (alpha-bungarotoxin-reversible) mechanism.
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Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist
2005
Pharmacokinetics of therapeutic doses of tropisetron in healthy volunteers
2001
Short-term treatment of primary fibromyalgia with the 5-HT3-receptor antagonist tropisetron: randomized, double-blind, placebo-controlled multicenter trial in 418 patients (Int J Clin Pharmacol Res 2001 — journal corrected from source dossier)
Prices verified as of July 2026. Actual prices may vary. For research use only.
2001
Disclosed Labs