Semax

Overview

Semax is a synthetic peptide analog of ACTH (4-7). It has been studied for cognitive enhancement, neuroprotection, and is approved in Russia for stroke recovery and cognitive impairment.

Mechanism of Action

Semax modulates BDNF and NGF expression, affects monoamine neurotransmitter systems, and has shown neuroprotective effects possibly through melanocortin receptor activation.

Research Summary

Approved in Russia and Ukraine for stroke recovery, cognitive disorders, and peptic ulcers. Preclinical studies demonstrate neuroprotection against ischemic damage and improved memory formation. Its nootropic effects are well-documented in Russian medical literature.

Dosing Information

Reported Side Effects

• Nasal dryness or irritation
• Mild headache
• Dizziness
• Hair loss (rare, at high doses)

Labs to monitor before & during your Semax protocol

These biomarkers are commonly tracked to assess response and safety. Run baseline labs before starting, mid-cycle labs halfway through, and post-cycle labs 1–2 weeks after the final dose.

Commonly Stacked With

Research References

• Ashmarin IP, et al. Regulatory Peptides. 2005;25(1):75-88.