Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Head-to-head comparison of Selank and Semax — mechanism, dosing, side effects, legal status, and pricing.
Selank is a synthetic heptapeptide analog of the endogenous immunomodulatory tetrapeptide tuftsin, extended with a Pro-Gly-Pro C-terminus for metabolic stability. Developed at the Institute of Molecular Genetics (Russian Academy of Sciences), it is registered as an anxiolytic drug in Russia but is not approved by the FDA or EMA.
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4-10) with a Pro-Gly-Pro C-terminal extension for metabolic stability. It was developed at the Institute of Molecular Genetics (Russian Academy of Sciences) and registered as a drug in Russia in 1994. It is not FDA-approved.
Selank
Semax
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Registered in Russia as a 0.15% nasal solution for generalized anxiety disorder and asthenic conditions. The pivotal Russian comparison by Zozulia et al. (2008) reported anxiolytic efficacy comparable to medazepam with additional antiasthenic effects. The evidence base is primarily Russian-language literature; no US or EU regulatory trials have been conducted.
Key references
Registered in Russia (1994) as intranasal drops in 0.1% (cognitive/asthenic indications) and 1% (acute ischemic stroke and optic nerve disease) formulations. Russian clinical trials (Gusev, Skvortsova and colleagues) reported improved neurological recovery when started early in acute ischemic stroke. Primary evidence base is Russian-language literature; no Western regulatory approvals and no pivotal Western trials exist.
Key references
Selank and Semax are both in the Cognitive category and may have overlapping mechanisms. Researchers should review both profiles carefully, understand the mechanisms of action, and monitor the relevant biomarkers when combining compounds in the same class. As always, consult a licensed healthcare provider before making any decisions about combining research compounds.
This platform provides informational tools only, not medical advice. This comparison is for educational purposes only. Consult a licensed provider.
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