DSIP

Overview

DSIP is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated in 1977 from the cerebral blood of rabbits during electrically induced sleep. Mechanism remains uncertain and the clinical evidence base is weak. Not FDA-approved — research use only.

Mechanism of Action

Mechanism is genuinely uncertain after decades of study. No specific DSIP receptor has been identified. Reported effects include modulation of CRH/cortisol signaling and interactions with GABAergic and monoaminergic systems, but these findings are inconsistent. Contemporary reviews describe DSIP as a 'still unresolved riddle.'

Research Summary

Schoenenberger & Monnier first isolated and characterized DSIP in 1977 (PNAS 74(3):1282-6, PMID 265572). Graf & Kastin's 1984 review (Neurosci Biobehav Rev, PMID 6145137) summarized the first decade of work, noting reported effects on sleep, pain, and stress but also substantial inconsistency across labs and species. Schneider-Helmert (Eur Neurol 1986, PMID 3792404) reported sleep normalization in 18 middle-aged and elderly chronic insomniacs given DSIP over one week — small, open, and never replicated at scale. Schneider-Helmert et al. (Dtsch Med Wochenschr 1987, PMID 3582201) explored phase-shifted insomnia. Kovalzon & Strekalova (J Neurochem 2006, PMID 16539679) summarized the field as a 'still unresolved riddle,' noting that no DSIP receptor or gene has been identified. No Phase 3 trials, no FDA approval, no modern controlled replication.

Vendors selling DSIP

Scored vendors carrying DSIP, ranked by trust grade. Grades are computed from indexed Certificates of Analysis. Full $/mg pricing is on the comparison page.

Prescribers who offer DSIP

45 prescribers in our directory work with DSIP, each confirmed from their own website. Peptides like DSIP require a prescription from a licensed provider — telehealth options are available.

Reported Side Effects

• Generally well-tolerated in small trials
• Injection-site reactions
• Vivid dreams (reported)
• Mild GI upset (reported)
• Mild headache

Biomarkers researchers track for DSIP

These biomarkers appear in the research literature as measures of response and safety for this compound.

Related Peptides

Compare DSIP with Others

Research References

• Schoenenberger GA, Monnier M. Characterization of a delta-EEG (-sleep)-inducing peptide. PNAS. 1977;74(3):1282-6. (PMID 265572)
• Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984;8(1):83-93. (PMID 6145137)
• Schneider-Helmert D. Efficacy of DSIP to normalize sleep in middle-aged and elderly chronic insomniacs. Eur Neurol. 1986;25(6):448-53. (PMID 3792404)
• Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-9. (PMID 16539679)

Frequently asked questions

Has DSIP been independently lab-tested?

Disclosed Labs has collected 71 Certificates of Analysis (COA) for DSIP from 14 independent testing labs. 31 vendors have submitted material for testing. Products average 99.4% tested purity across the corpus. Full testing data is available at https://www.disclosedlabs.com/peptides/dsip/testing.

What is the average purity of DSIP on the market?

Based on 71 COAs analyzed by Disclosed Labs, DSIP products average 99.4% (±0.5%) tested purity. Individual vendor results vary; see per-vendor COA data at https://www.disclosedlabs.com/peptides/dsip/coas.

Which labs have tested DSIP?

Independent labs that have tested DSIP include: ILS Labs (Grade A), Ethos Analytics (Grade B). Full lab credibility grades and profiles are at https://www.disclosedlabs.com/labs.

Where can researchers source DSIP?

8 vendors with Disclosed Labs trust grades currently list DSIP, including Instant Peptides, Glacier Aminos, Ion Peptide. Compare live prices and lab-verified COAs at https://www.disclosedlabs.com/prices/dsip.

Which prescribers offer DSIP with a prescription?

45 prescribers in the Disclosed Labs directory work with DSIP, each confirmed from their own website, with telehealth options available. DSIP requires a prescription from a licensed provider. Browse them at https://www.disclosedlabs.com/prescribers?peptide=DSIP.

How does DSIP work?

Mechanism is genuinely uncertain after decades of study. No specific DSIP receptor has been identified. Reported effects include modulation of CRH/cortisol signaling and interactions with GABAergic and monoaminergic systems, but these findings are inconsistent. Contemporary reviews describe DSIP as a 'still unresolved riddle.'

What does the research say about DSIP?

Schoenenberger & Monnier first isolated and characterized DSIP in 1977 (PNAS 74(3):1282-6, PMID 265572). Graf & Kastin's 1984 review (Neurosci Biobehav Rev, PMID 6145137) summarized the first decade of work, noting reported effects on sleep, pain, and stress but also substantial inconsistency across labs and species. Schneider-Helmert (Eur Neurol 1986, PMID 3792404) reported sleep normalization in 18 middle-aged and elderly chronic insomniacs given DSIP over one week — small, open, and never replicated at scale. Schneider-Helmert et al. (Dtsch Med Wochenschr 1987, PMID 3582201) explored phase-shifted insomnia. Kovalzon & Strekalova (J Neurochem 2006, PMID 16539679) summarized the field as a 'still unresolved riddle,' noting that no DSIP receptor or gene has been identified. No Phase 3 trials, no FDA approval, no modern controlled replication.