Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
L-Tetrahydropalmatine (L-THP) is a non-peptide isoquinoline alkaloid naturally occurring in Corydalis yanhusuo and Stephania rotunda. It acts as a mixed dopamine receptor antagonist with affinity for D1, D2, D3, serotonin 5-HT1A, and alpha-1 adrenergic receptors, and facilitates GABA-A receptor binding. One randomized controlled trial in schizophrenia found no efficacy on psychiatric symptoms and unexpectedly raised inflammatory markers. Widely sold by gray-market vendors as a research chemical labeled “not for human consumption.”
Verified purity per dollar — the cheapest that's actually been tested
vial · 10000mg· kimerachems.co· price updated 3d ago
Lot KC-THP-02· tested 2025-08-26
$51.99✓ $0.005/mg
single-vial price — packs may be lower
Single-vial list prices by default for a fair head-to-head — switch to Multi-vial / bulk for pack pricing. Estimates only; verify at vendor before purchase. For research use only. Not medical advice.
Kimera Chems has the lowest single-vial L-Tetrahydropalmatine (L-THP) price at $0.005/mg among 2 COA-verified vendors on Disclosed Labs. Bulk or multi-vial deals may be lower.
What is the price range for L-Tetrahydropalmatine (L-THP)?
Research-grade L-Tetrahydropalmatine (L-THP) is listed at $0.005/mg from 1 verified source on Disclosed Labs.
How are L-Tetrahydropalmatine (L-THP) prices verified on Disclosed Labs?
Every listed vendor holds a Grade C or better trust score, computed independently from lab Certificates of Analysis — not from payments or sponsorships. Prices are scraped and fact-checked daily. Vendors cannot pay to improve their ranking.
Check formulation: Lyophilized powder requires reconstitution before use. Pre-mixed solutions are more convenient but may have a shorter shelf life and higher prices.
Compare per-mg cost: Different strengths and quantities make direct price comparison difficult. Calculate the per-milligram cost to find the true best value.
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One completed randomized, double-blind, placebo-controlled trial (NCT02118610; 63 adults with schizophrenia, 60 mg/day L-THP vs placebo for 4 weeks) found no significant benefit on positive, negative, depressive, or global symptom measures. The trial did show reduced extrapyramidal symptoms (p<.001, possibly confounded by anticholinergic co-medication) but unexpectedly raised inflammatory markers (sICAM-1 p=.004, CRP p=.039) rather than lowering them as animal data had suggested. Preclinical studies in rats demonstrated dose-dependent reductions in methamphetamine self-administration and reinstatement (1.25–5.0 mg/kg IP), reduced cocaine self-administration breaking points and discrimination (1.875–7.5 mg/kg), and decreased voluntary ethanol drinking in mice (10 mg/kg) via D2-receptor-mediated PKA signaling in dorsal striatum, without affecting locomotor activity at lower doses.
This platform provides informational tools only, not medical advice.
L-Tetrahydropalamatine: A Potential New Medication for the Treatment of Cocaine Addiction
2013
Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement
2016
Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats
Prices verified as of July 2026. Actual prices may vary. For research use only.
2010
Disclosed Labs