Humanin

Overview

Humanin is a mitochondrial-derived peptide encoded within the 16S ribosomal RNA gene. It was discovered through its ability to protect neurons from Alzheimer's disease-related toxicity and is studied for neuroprotection, metabolic regulation, and anti-aging applications.

Mechanism of Action

Humanin binds to FPRL1 (formyl peptide receptor-like 1) and BAX protein, inhibiting mitochondrial apoptosis in stressed cells. It also activates the STAT3 pathway and interacts with IGFBP-3, modulating IGF-1 signaling. In the brain, it protects neurons from amyloid-beta toxicity and oxidative stress through both intracellular and extracellular mechanisms.

Research Summary

Hashimoto et al. (2001) discovered humanin through functional screening for neuroprotective factors against amyloid-beta toxicity. Yen et al. characterized the S14G-Humanin analog (HNG) as 1000x more potent. Muzumdar et al. demonstrated that humanin improves insulin sensitivity and reduces visceral fat in animal models. Circulating humanin levels decline with age and correlate inversely with Alzheimer's biomarkers. Cohen et al. showed humanin's role in the GH/IGF-1 axis through IGFBP-3 interaction. No human clinical trials have been conducted — all dosing is extrapolated from preclinical data.

Vendors selling Humanin

Scored vendors carrying Humanin, ranked by trust grade. Grades are computed from indexed Certificates of Analysis. Full $/mg pricing is on the comparison page.

Prescribers who offer Humanin

4 prescribers in our directory work with Humanin, each confirmed from their own website. Peptides like Humanin require a prescription from a licensed provider.

Reported Side Effects

• Injection site reactions
• Headache
• Mild nausea
• Unknown long-term effects

Compare Humanin with Others

Research References

• A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta (Hashimoto et al., PNAS — original humanin discovery) (2001)
• Humanin: a novel central regulator of peripheral insulin action (Muzumdar et al., PLOS ONE) (2009)
• N-Formylated humanin activates both formyl peptide receptor-like 1 and 2 (Harada et al., BBRC) (2004)
• The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan (Yen et al., Aging) (2020)

Frequently asked questions

Has Humanin been independently lab-tested?

Disclosed Labs has collected 3 Certificates of Analysis (COA) for Humanin from 2 independent testing labs. 3 vendors have submitted material for testing. Products average 99.5% tested purity across the corpus. Full testing data is available at https://www.disclosedlabs.com/peptides/humanin/testing.

What is the average purity of Humanin on the market?

Based on 3 COAs analyzed by Disclosed Labs, Humanin products average 99.5% (±0.3%) tested purity. Individual vendor results vary; see per-vendor COA data at https://www.disclosedlabs.com/peptides/humanin/coas.

Where can researchers source Humanin?

1 vendor with Disclosed Labs trust grades currently list Humanin, including Kimera Chems. Compare live prices and lab-verified COAs at https://www.disclosedlabs.com/prices/humanin.

Which prescribers offer Humanin with a prescription?

4 prescribers in the Disclosed Labs directory work with Humanin, each confirmed from their own website. Humanin requires a prescription from a licensed provider. Browse them at https://www.disclosedlabs.com/prescribers?peptide=Humanin.

How does Humanin work?

Humanin binds to FPRL1 (formyl peptide receptor-like 1) and BAX protein, inhibiting mitochondrial apoptosis in stressed cells. It also activates the STAT3 pathway and interacts with IGFBP-3, modulating IGF-1 signaling. In the brain, it protects neurons from amyloid-beta toxicity and oxidative stress through both intracellular and extracellular mechanisms.

What does the research say about Humanin?

Hashimoto et al. (2001) discovered humanin through functional screening for neuroprotective factors against amyloid-beta toxicity. Yen et al. characterized the S14G-Humanin analog (HNG) as 1000x more potent. Muzumdar et al. demonstrated that humanin improves insulin sensitivity and reduces visceral fat in animal models. Circulating humanin levels decline with age and correlate inversely with Alzheimer's biomarkers. Cohen et al. showed humanin's role in the GH/IGF-1 axis through IGFBP-3 interaction. No human clinical trials have been conducted — all dosing is extrapolated from preclinical data.