Hormone Peptides

Bremelanotide

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist originally derived from Melanotan II. Unlike PDE5 inhibitors, it acts centrally on MC4R pathways in the brain rather than on peripheral vasculature, which is why research has extended beyond erectile function into libido and arousal pathways in both sexes. It is FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women. Research dosing is 1–2mg subcutaneously as needed. Researchers monitor blood pressure, testosterone, SHBG, and estradiol — blood pressure especially, since transient elevations are the most common side effect.

KP-10

Kisspeptin-10 is a truncated fragment of the kisspeptin neuropeptide that plays a central role in reproductive hormone signaling. It is a potent stimulator of GnRH release and is studied for its role in fertility, puberty, and hypogonadism.

GnRH

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH) used to maintain fertility and endogenous testosterone production during TRT. It is commonly co-prescribed with testosterone replacement therapy to prevent testicular atrophy and preserve HPG axis function.

Androxal

Enclomiphene is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM) that stimulates endogenous testosterone production. While not a peptide, it is widely tracked in the peptide and TRT community as an alternative or adjunct to testosterone replacement therapy.

Pitocin (synthetic IV)

Oxytocin is a nine-amino acid neuropeptide produced in the hypothalamus that plays a key role in social bonding, sexual reproduction, and maternal behavior. Intranasal oxytocin is studied for autism spectrum disorder, social anxiety, PTSD, and relationship therapy.

Examorelin

Hexarelin is a synthetic hexapeptide growth hormone secretagogue (GHS) that binds the ghrelin receptor (GHS-R1a). It is one of the most potent peptide-based GH secretagogues, with additional cardioprotective properties studied in preclinical models.

Lys-Glu-Asp-Gly

Testagen is a synthetic tetrapeptide (Lys-Glu-Asp-Gly) from the Khavinson bioregulator series, studied for potential effects on testicular function, Leydig cell signaling, and age-related changes in gonadal hormone pathways.

Tesa/Ipa

Pre-mixed blend of Tesamorelin (GHRH analog) and Ipamorelin (selective GHRP). An alternative to the CJC-1295/Ipamorelin combination, using the FDA-approved GHRH analog Tesamorelin for the GHRH-axis component.