Kisspeptin-10

Overview

Kisspeptin-10 (KP-10) is the 10-amino-acid C-terminal fragment of kisspeptin (the KISS1 gene product, also called metastin) that retains full biological activity. It is an investigational signaling peptide that sits at the top of the reproductive axis and is studied for fertility, hypogonadism, and as a diagnostic challenge. It is not FDA-approved.

Mechanism of Action

Kisspeptin-10 binds KISS1R (GPR54) on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. GnRH then drives LH and FSH secretion from the anterior pituitary, which stimulates downstream gonadal sex hormone production. Kisspeptin signaling is recognized as the upstream regulator of HPG-axis onset at puberty.

Research Summary

The foundational role of kisspeptin in reproduction was established by de Roux et al. (PNAS, 2003, PMID 12944565) and Seminara et al. (NEJM, 2003, PMID 14573733), who identified loss-of-function mutations in GPR54 causing hypogonadotropic hypogonadism. Dhillo et al. (JCEM, 2005) showed kisspeptin-54 stimulates LH, FSH, and testosterone in men; George et al. (JCEM, 2011, PMID 21632807) confirmed IV kisspeptin-10 boluses stimulate LH and increase pulse frequency in men. Young et al. (Neuroendocrinology, 2012, PMID 22377698) showed kisspeptin infusion restores pulsatile LH in patients with neurokinin B (TAC3/TACR3) signaling deficiencies. Abbara/Jayasena and colleagues (JCEM 2015, PMID 26192876; Hum Reprod 2017, PMID 28854728) demonstrated kisspeptin-54 can trigger oocyte maturation in IVF with very low OHSS rates. The kisspeptin receptor agonist MVT-602 has been in Phase 2 development for female HSDD. Grey-market SubQ use (~200 mcg 2x/week for libido or testosterone support) is not supported by controlled trials.

Vendors selling Kisspeptin-10

Scored vendors carrying Kisspeptin-10, ranked by trust grade. Grades are computed from indexed Certificates of Analysis. Full $/mg pricing is on the comparison page.

Prescribers who offer Kisspeptin-10

18 prescribers in our directory work with Kisspeptin-10, each confirmed from their own website. Peptides like Kisspeptin-10 require a prescription from a licensed provider.

Reported Side Effects

• Transient flushing
• Mild headache
• Injection site discomfort
• Generally well tolerated at research doses

Compare Kisspeptin-10 with Others

Research References

• Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men (George et al., JCEM) (2011)
• Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies (Young et al., Neuroendocrinology) (2012)
• The GPR54 gene as a regulator of puberty (Seminara et al., NEJM) (2003)

Frequently asked questions

Has Kisspeptin-10 been independently lab-tested?

Disclosed Labs has collected 60 Certificates of Analysis (COA) for Kisspeptin-10 from 11 independent testing labs. 25 vendors have submitted material for testing. Products average 99.6% tested purity across the corpus. Full testing data is available at https://www.disclosedlabs.com/peptides/kisspeptin-10/testing.

What is the average purity of Kisspeptin-10 on the market?

Based on 60 COAs analyzed by Disclosed Labs, Kisspeptin-10 products average 99.6% (±0.3%) tested purity. Individual vendor results vary; see per-vendor COA data at https://www.disclosedlabs.com/peptides/kisspeptin-10/coas.

Which labs have tested Kisspeptin-10?

Independent labs that have tested Kisspeptin-10 include: ILS Labs (Grade A). Full lab credibility grades and profiles are at https://www.disclosedlabs.com/labs.

Where can researchers source Kisspeptin-10?

8 vendors with Disclosed Labs trust grades currently list Kisspeptin-10, including Instant Peptides, Glacier Aminos, Ion Peptide. Compare live prices and lab-verified COAs at https://www.disclosedlabs.com/prices/kisspeptin-10.

Which prescribers offer Kisspeptin-10 with a prescription?

18 prescribers in the Disclosed Labs directory work with Kisspeptin-10, each confirmed from their own website. Kisspeptin-10 requires a prescription from a licensed provider. Browse them at https://www.disclosedlabs.com/prescribers?peptide=Kisspeptin-10.

How does Kisspeptin-10 work?

Kisspeptin-10 binds KISS1R (GPR54) on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. GnRH then drives LH and FSH secretion from the anterior pituitary, which stimulates downstream gonadal sex hormone production. Kisspeptin signaling is recognized as the upstream regulator of HPG-axis onset at puberty.

What does the research say about Kisspeptin-10?

The foundational role of kisspeptin in reproduction was established by de Roux et al. (PNAS, 2003, PMID 12944565) and Seminara et al. (NEJM, 2003, PMID 14573733), who identified loss-of-function mutations in GPR54 causing hypogonadotropic hypogonadism. Dhillo et al. (JCEM, 2005) showed kisspeptin-54 stimulates LH, FSH, and testosterone in men; George et al. (JCEM, 2011, PMID 21632807) confirmed IV kisspeptin-10 boluses stimulate LH and increase pulse frequency in men. Young et al. (Neuroendocrinology, 2012, PMID 22377698) showed kisspeptin infusion restores pulsatile LH in patients with neurokinin B (TAC3/TACR3) signaling deficiencies. Abbara/Jayasena and colleagues (JCEM 2015, PMID 26192876; Hum Reprod 2017, PMID 28854728) demonstrated kisspeptin-54 can trigger oocyte maturation in IVF with very low OHSS rates. The kisspeptin receptor agonist MVT-602 has been in Phase 2 development for female HSDD. Grey-market SubQ use (~200 mcg 2x/week for libido or testosterone support) is not supported by controlled trials.