Kisspeptin-10

Overview

Kisspeptin-10 is a truncated fragment of the kisspeptin neuropeptide that plays a central role in reproductive hormone signaling. It is a potent stimulator of GnRH release and is studied for its role in fertility, puberty, and hypogonadism.

Mechanism of Action

Kisspeptin-10 binds to the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering the release of gonadotropin-releasing hormone. This cascade stimulates the pituitary to release LH and FSH, driving downstream testosterone and estrogen production.

Research Summary

Clinical studies demonstrate that kisspeptin administration robustly stimulates LH and FSH release in both men and women. It is studied as a diagnostic tool for reproductive disorders and as a potential treatment for hypothalamic amenorrhea and male hypogonadism. Research is primarily conducted at Imperial College London.

Dosing Information

Reported Side Effects

• Injection site discomfort
• Flushing
• Headache
• Mild nausea

Research References

• Kisspeptin-10 administration to men reveals an emerging role in neuroendocrine regulation of reproduction (2011)
• Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies (2013)
• Kisspeptins and reproduction: physiological roles and regulatory mechanisms (2012)