Enclomiphene

Overview

Enclomiphene is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM) that stimulates endogenous testosterone production. While not a peptide, it is widely tracked in the peptide and TRT community as an alternative or adjunct to testosterone replacement therapy.

Mechanism of Action

Enclomiphene blocks estrogen receptors in the hypothalamus, reducing negative feedback and stimulating increased GnRH release. This drives elevated LH and FSH secretion from the pituitary, resulting in increased testicular testosterone production without the estrogenic side effects associated with the zu-isomer (zuclomiphene).

Research Summary

Phase 3 clinical trials (ZA-301, ZA-302) demonstrated significant increases in serum testosterone to eugonadal levels while maintaining or improving sperm counts. Despite positive Phase 3 results, enclomiphene has not received FDA approval. It is considered a promising alternative to TRT for men who wish to preserve fertility.

Dosing Information

Reported Side Effects

• Headache
• Hot flashes
• Mood changes
• Visual disturbances (rare)
• Elevated liver enzymes

Research References

• Enclomiphene citrate stimulates testosterone production while maintaining sperm production (2013)
• Oral enclomiphene citrate versus injectable testosterone for secondary hypogonadism (2016)
• Enclomiphene citrate: a potential treatment for hypogonadism with preserved fertility (2015)