Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
The trans-isomer of clomiphene citrate, a SERM that stimulates endogenous testosterone production. Not a peptide, but widely used alongside peptide protocols for hormone optimization.
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Lowest $/mg for Enclomiphene · last 8 days
$7.60/mg
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vial · 12.5mgnovapeptidesupply.com· price updated today
$8.00/mg
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Wiehle et al. (BJU Int 2013, PMID 23875626) established pharmacokinetics and demonstrated testosterone restoration to the normal range in men with secondary hypogonadism. Kaminetsky et al. (J Sex Med 2013, PMID 23530575) showed enclomiphene raised testosterone and sperm counts while testosterone gel suppressed gonadotropins and spermatogenesis. Phase 3 trials ZA-304 and ZA-305 (Kim et al., BJU Int 2016, PMID 26496621) confirmed efficacy in overweight/obese hypogonadal men with superior preservation of LH, FSH, and sperm counts versus AndroGel 1.62%. Despite these positive data, the FDA issued Complete Response Letters to Repros Therapeutics in 2014 and 2016; Androxal was never approved and Repros subsequently wound down. As of April 2026 no FDA-approved enclomiphene exists. It is dispensed off-label via 503A compounding pharmacies for secondary hypogonadism and post-TRT/HPTA restart.
This platform provides informational tools only, not medical advice.
Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study (Wiehle et al., BJU Int)
2013
Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel (Kaminetsky et al., J Sex Med)
2013
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement (Kim et al., BJU Int — Phase 3 ZA-304/ZA-305)
Prices verified as of June 2026. Actual prices may vary. For research use only.
2016