Thymogen

Overview

Thymogen (also marketed as Thymagen) is a synthetic dipeptide, L-Glu-L-Trp (Glu-Trp), originally isolated by the Khavinson group from the calf-thymus polypeptide complex Thymalin and then synthesized. It is registered as a pharmaceutical in Russia for immunocorrection (nasal drops / IM injection). Not FDA-approved in the US; research-use only.

Mechanism of Action

Proposed to activate T-cell differentiation and MHC-peptide recognition, modulate intracellular cyclic nucleotides, and enhance neutrophil chemotaxis and phagocytosis. Mechanistic claims come primarily from the Khavinson group and Russian immunology literature.

Research Summary

Evidence base is single-lab (Khavinson and collaborators). A 12-month rat study (Anisimov, Khavinson, Morozov, Biogerontology 2000) reported extended maximum lifespan and reduced spontaneous tumor incidence. Russian clinical reports claim benefit in acute/chronic respiratory infections and post-surgical immunodeficiency; these have not been independently reproduced in Western RCTs.

Vendors selling Thymogen

Scored vendors carrying Thymogen, ranked by trust grade. Grades are computed from indexed Certificates of Analysis. Full $/mg pricing is on the comparison page.

Reported Side Effects

• Mild injection site irritation
• Rare hypersensitivity

Compare Thymogen with Others

Research References

• Anisimov, Khavinson, Morozov — Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats (Biogerontology) (2000)
• Khavinson et al. — The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity (includes Glu-Trp / Thymogen, Biol Bull Rev) (2021)
• Khavinson, Kuznik, Ryzhak — Peptide bioregulators: clinical studies results (covers Thymogen/Timogen, Adv Gerontol, Russian) (2013)

Frequently asked questions

Has Thymogen been independently lab-tested?

Disclosed Labs has collected 12 Certificates of Analysis (COA) for Thymogen from 5 independent testing labs. 4 vendors have submitted material for testing. Products average 99.7% tested purity across the corpus. Full testing data is available at https://www.disclosedlabs.com/peptides/thymogen/testing.

What is the average purity of Thymogen on the market?

Based on 12 COAs analyzed by Disclosed Labs, Thymogen products average 99.7% (±0.2%) tested purity. Individual vendor results vary; see per-vendor COA data at https://www.disclosedlabs.com/peptides/thymogen/coas.

Where can researchers source Thymogen?

2 vendors with Disclosed Labs trust grades currently list Thymogen, including BioLongevity Labs, Kimera Chems. Compare live prices and lab-verified COAs at https://www.disclosedlabs.com/prices/thymogen.

How does Thymogen work?

Proposed to activate T-cell differentiation and MHC-peptide recognition, modulate intracellular cyclic nucleotides, and enhance neutrophil chemotaxis and phagocytosis. Mechanistic claims come primarily from the Khavinson group and Russian immunology literature.

What does the research say about Thymogen?

Evidence base is single-lab (Khavinson and collaborators). A 12-month rat study (Anisimov, Khavinson, Morozov, Biogerontology 2000) reported extended maximum lifespan and reduced spontaneous tumor incidence. Russian clinical reports claim benefit in acute/chronic respiratory infections and post-surgical immunodeficiency; these have not been independently reproduced in Western RCTs.