Peptide Database/Mots-C

MetabolicCategory 1 — Legally Compoundable

Mots-C

Mitochondrial ORF of the 12S rRNA Type-C

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Reconstitution

Overview

Mots-C is a mitochondrial-derived peptide that has been studied for metabolic regulation, exercise performance enhancement, and potential anti-aging effects.

Mechanism of Action

Mots-C activates AMPK pathway, regulates metabolic homeostasis, and has been shown to improve glucose uptake and utilization. It may also enhance exercise capacity through improved mitochondrial function.

Research Summary

Preclinical studies in mice demonstrate improved insulin sensitivity, prevention of age-related metabolic dysfunction, and enhanced exercise capacity. Endogenous MOTS-c levels decline with age and correlate with metabolic fitness. Human trials are limited but emerging.

Dosing Information

Typical Dose

5mg

Range

5-10mg

Frequency

3x/week (subcutaneous)

Route

SubQ

Duration

4-8 weeks

Reconstitution

10mg vial + 2mL bacteriostatic water = 5,000mcg/mL

Notes

Typically dosed 5 mg three to five times per week in research settings. Often cycled 4–8 weeks. Best administered on training days for potential synergistic effects with exercise.

Reported Side Effects

Injection site reactions
Mild nausea
Temporary fatigue
Headache

Contraindications

Active cancer (AMPK activation may affect tumor metabolism variably)
Pregnancy or breastfeeding
Severe hepatic impairment

Labs to monitor before & during your Mots-C protocol

These biomarkers are commonly tracked to assess response and safety. Run baseline labs before starting, mid-cycle labs halfway through, and post-cycle labs 1–2 weeks after the final dose.

Fasting glucoseInsulinLactateCRPHbA1c

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Commonly Stacked With

Semaglutide Epithalon

Research References

Lee C, et al. Cell Metabolism. 2015;21(3):443-454.
Reynolds JC, et al. Cell Metabolism. 2021;33(1):174-188.

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Build a protocol with Mots-C, schedule blood work for key biomarkers, and track your results.

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This platform provides informational tools only, not medical advice. This information is for educational purposes only. Consult a licensed provider.

Dosing Information

Typical Dose

5mg

Range

5-10mg

Frequency

3x/week (subcutaneous)

Route

SubQ

Duration

4-8 weeks

Reconstitution

10mg vial + 2mL bacteriostatic water = 5,000mcg/mL

Notes

Typically dosed 5 mg three to five times per week in research settings. Often cycled 4–8 weeks. Best administered on training days for potential synergistic effects with exercise.