Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Head-to-head comparison of Meldonium and SR-9011 — mechanism, dosing, side effects, legal status, and pricing.
Meldonium (Mildronate) is a small-molecule carnitine-biosynthesis inhibitor and anti-ischemic metabolic modulator — not a peptide. It is an approved prescription drug for cardiovascular indications in several ex-Soviet states but is not FDA- or EMA-approved, and it is WADA-prohibited (added January 2016, of Sharapova notoriety). It is also sold as a gray-market research chemical.
SR-9011 is a synthetic small-molecule REV-ERB (Rev-erbα/β) agonist — not a peptide — studied preclinically as a circadian/metabolic modulator. It has no human data of any kind, no regulatory approval, and is WADA-prohibited at all times. Note: it is frequently confused with "Stenabolic," which is properly its analog SR9009, not SR-9011.
Meldonium
SR-9011
Category
Legal Status
Mechanism
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Frequency
COA-verified vendors · trust score ≥70 required · single-vial price — bulk/bundle deals may be lower
Meldonium
No pricing data yet.
Check Meldonium prices →SR-9011
COA corpus from Disclosed Labs — independently tested batches only.
Meldonium
2
COAs
99.9%
Avg purity
2
Labs
SR-9011
1
COAs
96.8%
Avg purity
1
Labs
In rat ischemia-reperfusion models, meldonium (100–200 mg/kg) reduced myocardial infarct size ~30% and protected liver, brain, and endothelial function. In humans it is used clinically (in approving markets) for chronic heart failure and angina at 500 mg twice daily, but there is no FDA/EMA-registered pivotal efficacy trial. Urinary detection persists for weeks-to-months, central to doping cases. Not FDA/EMA-approved; not a peptide.
In diet-induced obese mice (intraperitoneal dosing), SR-9011/SR9009 increased energy expenditure, reduced fat mass, and improved dyslipidemia and hyperglycemia (Solt et al., Nature 2012). Human liver microsome work identified 14 metabolites but no half-life, and the authors caution against human extrapolation. There are no registered human trials of SR-9011; no human safety, dose, or pharmacokinetic data exist.
Meldonium and SR-9011 are both in the Metabolic category and may have overlapping mechanisms. Researchers should review both profiles carefully, understand the mechanisms of action, and monitor the relevant biomarkers when combining compounds in the same class. As always, consult a licensed healthcare provider before making any decisions about combining research compounds.
This platform provides informational tools only, not medical advice. This comparison is for educational purposes only. Consult a licensed provider.
Dosing Notes
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Lab Testing
Disclosed Labs