Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Head-to-head comparison of Humanin and Thymulin — mechanism, dosing, side effects, legal status, and pricing.
Humanin is a mitochondrial-derived peptide encoded within the 16S ribosomal RNA gene. It was discovered through its ability to protect neurons from Alzheimer's disease-related toxicity and is studied for neuroprotection, metabolic regulation, and anti-aging applications.
Thymulin is a zinc-dependent nonapeptide (pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn) secreted by thymic epithelial cells, originally isolated by Bach and colleagues in the 1970s as 'facteur thymique sérique' (FTS). It is NOT the same compound as Thymalin (a Russian bovine thymus extract) or Thymosin alpha-1 (a separate 28-amino-acid thymic peptide). Thymulin is not FDA-approved; use is research/investigational only.
Humanin
Thymulin
Category
Legal Status
Mechanism
Dose Range
Route
Frequency
COA-verified vendors · trust score ≥70 required · single-vial price — bulk/bundle deals may be lower
Humanin
Thymulin
COA corpus from Disclosed Labs — independently tested batches only.
Humanin
3
COAs
99.5%
Avg purity
2
Labs
Thymulin
5
COAs
99.5%
Avg purity
4
Labs
Hashimoto et al. (2001) discovered humanin through functional screening for neuroprotective factors against amyloid-beta toxicity. Yen et al. characterized the S14G-Humanin analog (HNG) as 1000x more potent. Muzumdar et al. demonstrated that humanin improves insulin sensitivity and reduces visceral fat in animal models. Circulating humanin levels decline with age and correlate inversely with Alzheimer's biomarkers. Cohen et al. showed humanin's role in the GH/IGF-1 axis through IGFBP-3 interaction. No human clinical trials have been conducted — all dosing is extrapolated from preclinical data.
Key references
Bach and Dardenne originally characterized FTS/thymulin and its absolute zinc dependency (Bach & Dardenne, Med Oncol Tumor Pharmacother 1989, PMID 2657247). Prasad et al. (J Clin Invest 1988, PMID 3262625) showed that serum thymulin activity falls in human zinc deficiency and recovers with zinc supplementation. Mocchegiani et al. (Int J Immunopharmacol 1995, PMID 8582782) demonstrated partial reversal of thymic involution with zinc in aged mice. Dardenne & Pleau reviewed zinc-thymulin interactions (Met Based Drugs 1994, PMID 18476235). Safieh-Garabedian et al. (Br J Pharmacol 2002, PMID 12110619) reported analgesic/anti-inflammatory activity of a thymulin-related peptide in rats. There are NO large, modern RCTs of exogenous thymulin in humans; clinical use is experimental.
Humanin (Cognitive) and Thymulin (Immune) are in different categories and target different biological pathways. This is a common pattern in multi-compound research protocols. Researchers should monitor the biomarkers from both profiles and watch for interactions listed in each compound’s contraindications. Consult a licensed healthcare provider before combining any research compounds.
This platform provides informational tools only, not medical advice. This comparison is for educational purposes only. Consult a licensed provider.
Dosing Notes
Half-life
Side Effects
Contraindications
Lab Testing
Disclosed Labs