Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Head-to-head comparison of Alagebrium (ALT-711) and SR-9011 — mechanism, dosing, side effects, legal status, and pricing.
Alagebrium (ALT-711) is a thiazolium-derived non-peptide small molecule investigated as an advanced glycation end-product (AGE) crosslink breaker. It reached Phase I–III human trials (2001–2010) for diastolic heart failure and hypertension but was never approved; clinical development was discontinued around 2009 due to financial constraints. No validated human dose exists. Currently sold by research-chemical vendors for research use only.
SR-9011 is a synthetic small-molecule REV-ERB (Rev-erbα/β) agonist — not a peptide — studied preclinically as a circadian/metabolic modulator. It has no human data of any kind, no regulatory approval, and is WADA-prohibited at all times. Note: it is frequently confused with "Stenabolic," which is properly its analog SR9009, not SR-9011.
Alagebrium (ALT-711)
SR-9011
Category
Legal Status
Mechanism
Dose Range
Route
COA-verified vendors · trust score ≥70 required · single-vial price — bulk/bundle deals may be lower
Alagebrium (ALT-711)
SR-9011
COA corpus from Disclosed Labs — independently tested batches only.
Alagebrium (ALT-711)
2
COAs
99.6%
Avg purity
2
Labs
SR-9011
1
COAs
96.8%
Avg purity
1
Labs
Alagebrium reached Phase I–III human trials (2001–2010) under sponsor Alteon Inc./Synvista Therapeutics but was never approved. A 16-week open-label pilot in 23 elderly patients (21 completers) with diastolic heart failure showed reduced left ventricular mass and improved Doppler diastolic index (E') without change in blood pressure, ejection fraction, or exercise capacity. The SPECTRA trial (ALT-711 + hydrochlorothiazide in hypertension) was terminated; the BENEFICIAL trial (chronic heart failure) was completed but did not meet efficacy endpoints. Preclinical studies in non-diabetic hypertensive rats, aged dogs, aged monkeys, streptozotocin-induced diabetic rats, and diabetic mouse models demonstrated improved vascular/cardiac function, reduced aortic stiffness, decreased collagen crosslinking, and improved renal pathology. A 2-year rat toxicology study found liver alterations that prompted a temporary enrollment suspension pending review.
In diet-induced obese mice (intraperitoneal dosing), SR-9011/SR9009 increased energy expenditure, reduced fat mass, and improved dyslipidemia and hyperglycemia (Solt et al., Nature 2012). Human liver microsome work identified 14 metabolites but no half-life, and the authors caution against human extrapolation. There are no registered human trials of SR-9011; no human safety, dose, or pharmacokinetic data exist.
Alagebrium (ALT-711) and SR-9011 are both in the Metabolic category and may have overlapping mechanisms. Researchers should review both profiles carefully, understand the mechanisms of action, and monitor the relevant biomarkers when combining compounds in the same class. As always, consult a licensed healthcare provider before making any decisions about combining research compounds.
This platform provides informational tools only, not medical advice. This comparison is for educational purposes only. Consult a licensed provider.
Frequency
Dosing Notes
Side Effects
Contraindications
Lab Testing
Disclosed Labs