What is the difference between 3,5-Diiodo-L-thyronine (3,5-T2) and 5-Amino-1MQ?

3,5-Diiodo-L-thyronine (3,5-T2): 3,5-Diiodo-L-thyronine (3,5-T2) is a non-peptide endogenous iodothyronine produced by deiodination of T3 and T4. It is not an approved drug and has no registered human clinical trials as a study inter... 5-Amino-1MQ: 5-Amino-1MQ is a small heterocyclic molecule (not a peptide) that acts as a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). It is under preclinical investigation fo...

What does the research say about 3,5-Diiodo-L-thyronine (3,5-T2) vs 5-Amino-1MQ?

3,5-Diiodo-L-thyronine (3,5-T2): No approved human drug or registered interventional clinical trial exists. The only direct human-administration data are from a single 2-person case report: oral 3,5-T2 (~5 μg/kg body weight) for 28 days reportedly raised resting metabolic rate by ~15% and lowered body weight by ~4 kg, with no significant changes in principal clinical parameters an… 5-Amino-1MQ: Neelakantan et al. (2018, Biochem Pharmacol, PMID 29155147) reported that 5-Amino-1MQ and related selective, membrane-permeable methylquinolinium NNMT inhibitors reversed high-fat-diet-induced obesity in mice, reducing body weight, white adipose mass, adipocyte size, and plasma cholesterol without changing food intake. A separate NNMT inhibitor pro…

3,5-Diiodo-L-thyronine (3,5-T2) vs 5-Amino-1MQ

Q: Can you stack 3,5-Diiodo-L-thyronine (3,5-T2) and 5-Amino-1MQ?

3,5-Diiodo-L-thyronine (3,5-T2) (metabolic) and 5-Amino-1MQ (metabolic) are in the same category and may have overlapping mechanisms — researchers should review both profiles carefully before combining. Consult a licensed provider before combining any compounds.

Head-to-head comparison of 3,5-Diiodo-L-thyronine (3,5-T2) and 5-Amino-1MQ — mechanism, side effects, legal status, and pricing.

3,5-Diiodo-L-thyronine (3,5-T2)

3,5-Diiodo-L-thyronine (3,5-T2) is a non-peptide endogenous iodothyronine produced by deiodination of T3 and T4. It is not an approved drug and has no registered human clinical trials as a study intervention. The only direct human-administration data come from a single 2-person case report. WADA/anti-doping status for 3,5-T2 specifically is unconfirmed; a 2019 secondary source suggested thyroid hormones as a class were not prohibited, but no current primary WADA citation was found.

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5-Amino-1MQ

5-Amino-1MQ is a small heterocyclic molecule (not a peptide) that acts as a selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). It is under preclinical investigation for obesity and non-alcoholic fatty liver disease. It is not FDA-approved and has not completed human clinical trials; it is commonly tracked alongside peptides because grey-market vendors sell it for metabolic protocols.

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3,5-Diiodo-L-thyronine (3,5-T2)

5-Amino-1MQ

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5-Amino-1MQ

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3,5-Diiodo-L-thyronine (3,5-T2)

COAs

97.4%

Avg purity

Labs

Full testing data

5-Amino-1MQ

COAs

99.5%

Avg purity

Labs

Full testing data

3,5-Diiodo-L-thyronine (3,5-T2) Research Summary

No approved human drug or registered interventional clinical trial exists. The only direct human-administration data are from a single 2-person case report: oral 3,5-T2 (~5 μg/kg body weight) for 28 days reportedly raised resting metabolic rate by ~15% and lowered body weight by ~4 kg, with no significant changes in principal clinical parameters and no observed side effects. Endogenous 3,5-T2 has been measured in healthy human serum (~0.22–0.33 nM) and as a metabolite in liothyronine (T3) pharmacokinetic trials. Preclinical rodent studies show 3,5-T2 rapidly increases resting metabolic rate (faster than T3), reduces adiposity in high-fat-diet models by increasing fat oxidation, stimulates liver and skeletal muscle mitochondrial bioenergetics, and activates AMPK in skeletal muscle. One rat regimen (25 μg/100g BW, 4 weeks) showed no HPT-axis suppression or cardiac hypertrophy at that specific dose/duration; however, one mouse model (unsaturated-fat diet) showed no improvement in NAFLD or insulin sensitivity.

Key references

5-Amino-1MQ Research Summary

Neelakantan et al. (2018, Biochem Pharmacol, PMID 29155147) reported that 5-Amino-1MQ and related selective, membrane-permeable methylquinolinium NNMT inhibitors reversed high-fat-diet-induced obesity in mice, reducing body weight, white adipose mass, adipocyte size, and plasma cholesterol without changing food intake. A separate NNMT inhibitor program (Kannt et al., 2018, Sci Rep, PMID 29483571, JBSNF-000088) produced similar metabolic effects in rodents. Dimet-Wiley et al. (2022, Sci Rep, PMID 35013352) reported microbiome changes with NNMT inhibition plus low-fat diet in DIO mice, and Babula et al. (2024, Diabetes Obes Metab, PMID 39161060) showed 5A1MQ dose-dependently limited weight and fat gain and reduced NAFLD-like liver pathology in DIO mice. No human clinical trials of 5-Amino-1MQ have been completed or published as of 2026; grey-market oral protocols are not clinically validated.

Can you stack 3,5-Diiodo-L-thyronine (3,5-T2) and 5-Amino-1MQ?

3,5-Diiodo-L-thyronine (3,5-T2) and 5-Amino-1MQ are both in the Metabolic category and may have overlapping mechanisms. Researchers should review both profiles carefully, understand the mechanisms of action, and monitor the relevant biomarkers when combining compounds in the same class. As always, consult a licensed healthcare provider before making any decisions about combining research compounds.

Other comparisons

5-Amino-1MQ vs MOTS-c 3,5-Diiodo-L-thyronine (3,5-T2) vs MOTS-c 5-Amino-1MQ vs AOD-9604 3,5-Diiodo-L-thyronine (3,5-T2) vs AOD-9604 5-Amino-1MQ vs NAD+5-Amino-1MQ vs SLU-PP-915 5-Amino-1MQ vs SLU-PP-332 5-Amino-1MQ vs Glutathione

This platform provides informational tools only, not medical advice. This comparison is for educational purposes only. Consult a licensed provider.