5-Amino-1MQ

Overview

5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor studied for its anti-obesity and metabolic effects. While not a peptide, it is commonly tracked in the peptide space due to its use in metabolic optimization protocols. It reduces fat cell size and promotes energy expenditure.

Mechanism of Action

5-Amino-1MQ inhibits NNMT, an enzyme that methylates nicotinamide, depleting the SAM (S-adenosylmethionine) methyl donor pool. NNMT inhibition increases intracellular NAD+ levels, activates the SIRT1 pathway, and promotes fat oxidation. It shrinks fat cells by increasing cellular energy expenditure and reducing lipogenesis.

Research Summary

Preclinical studies in diet-induced obese mice show reduced body weight, decreased adipocyte size, and improved cholesterol profiles without changes in food intake. The compound reverses diet-induced obesity through enhanced cellular metabolism. Human clinical trials are not yet published.

Dosing Information

Reported Side Effects

• Headache
• Mild nausea
• Gastrointestinal discomfort
• Fatigue (transient)

Research References

• NNMT inhibition reverses diet-induced obesity by decreasing fat cell size (2014)
• Nicotinamide N-methyltransferase as a target for metabolic disease therapy (2017)
• NNMT: a potential therapeutic target for obesity and metabolic syndrome (2020)