Tesofensine

Overview

Tesofensine is a triple monoamine reuptake inhibitor (serotonin, noradrenaline, dopamine) originally developed for Parkinson's / Alzheimer's and later repurposed for obesity.

Mechanism of Action

Blocks reuptake of all three monoamines, increasing synaptic neurotransmitter levels. Drives appetite suppression and increased energy expenditure via dopaminergic and noradrenergic tone.

Research Summary

Phase II trial showed ~12% weight loss at 24 weeks (0.5mg/day). Approved in Mexico (2022) for obesity; not FDA-approved.

Dosing Information

Reported Side Effects

• Insomnia
• Dry mouth
• Elevated heart rate
• Hypertension
• Constipation