PEG-MGF

Overview

PEG-MGF is the PEGylated form of Mechano Growth Factor, a splice variant of IGF-1 that is expressed in response to mechanical stress on muscle tissue. PEGylation extends its half-life, making it practical for research and performance applications focused on muscle repair.

Mechanism of Action

MGF activates satellite (muscle stem) cells and promotes their proliferation, differentiation, and fusion with existing muscle fibers. Unlike systemic IGF-1, MGF acts locally at the site of muscle damage. PEGylation increases the plasma half-life from minutes to several hours, allowing for practical dosing schedules.

Research Summary

Preclinical studies demonstrate enhanced muscle repair and hypertrophy when MGF is administered after mechanical damage. PEG-MGF shows improved efficacy over unmodified MGF due to extended half-life. Human clinical data is limited. It is banned by WADA as a performance-enhancing substance.

Dosing Information

Reported Side Effects

• Injection site pain
• Localized swelling
• Hypoglycemia
• Joint pain

Research References

• Mechano growth factor: a splice variant of IGF-1 involved in muscle repair (2003)
• PEGylated mechano growth factor enhances satellite cell activation and muscle repair (2009)
• Insulin-like growth factor-I splice variants and muscle growth (2005)