Livagen

Overview

Livagen is a synthetic tetrapeptide (Lys-Glu-Asp-Ala / KEDA) from the Khavinson short-peptide 'bioregulator' series, developed at the St. Petersburg Institute of Bioregulation and Gerontology. Marketed in Russia primarily as a food-supplement-grade cytomax; not FDA-approved in the US; research-use only.

Mechanism of Action

Khavinson-group studies report that Livagen induces activation of ribosomal genes, decondensation of pericentromeric heterochromatin, and de-repression of genes silenced during aging in lymphocytes from elderly donors. Proposed activity is direct binding to DNA / chromatin. Western pharmacology literature has not independently characterized its mechanism.

Research Summary

Evidence base is essentially single-lab (Khavinson, Lezhava, and collaborators). In vitro studies on lymphocyte chromatin in elderly subjects and small Russian reports in chronic gastritis and immune senescence. No FDA-registered clinical trials and no Western RCTs.

Vendors selling Livagen

Scored vendors carrying Livagen, ranked by trust grade. Grades are computed from indexed Certificates of Analysis. Full $/mg pricing is on the comparison page.

Prescribers who offer Livagen

2 prescribers in our directory work with Livagen, each confirmed from their own website. Peptides like Livagen require a prescription from a licensed provider.

Reported Side Effects

• Injection site irritation
• Rare hypersensitivity

Compare Livagen with Others

Research References

• Khavinson et al. — Effects of Livagen peptide on chromatin activation in lymphocytes from old people (Bull Exp Biol Med) (2002)
• Khavinson, Lezhava, Malinin — Effects of short peptides on lymphocyte chromatin in senile subjects (includes Livagen, Bull Exp Biol Med) (2004)
• Khavinson, Kuznik, Ryzhak — Peptide bioregulators: clinical studies results (Adv Gerontol, Russian) (2013)

Frequently asked questions

Has Livagen been independently lab-tested?

Disclosed Labs has collected 9 Certificates of Analysis (COA) for Livagen from 5 independent testing labs. 5 vendors have submitted material for testing. Products average 99.6% tested purity across the corpus. Full testing data is available at https://www.disclosedlabs.com/peptides/livagen/testing.

What is the average purity of Livagen on the market?

Based on 9 COAs analyzed by Disclosed Labs, Livagen products average 99.6% (±0.3%) tested purity. Individual vendor results vary; see per-vendor COA data at https://www.disclosedlabs.com/peptides/livagen/coas.

Where can researchers source Livagen?

5 vendors with Disclosed Labs trust grades currently list Livagen, including Peptidology, Skye Peptides, Peptide Supply Co.. Compare live prices and lab-verified COAs at https://www.disclosedlabs.com/prices/livagen.

Which prescribers offer Livagen with a prescription?

2 prescribers in the Disclosed Labs directory work with Livagen, each confirmed from their own website. Livagen requires a prescription from a licensed provider. Browse them at https://www.disclosedlabs.com/prescribers?peptide=Livagen.

How does Livagen work?

Khavinson-group studies report that Livagen induces activation of ribosomal genes, decondensation of pericentromeric heterochromatin, and de-repression of genes silenced during aging in lymphocytes from elderly donors. Proposed activity is direct binding to DNA / chromatin. Western pharmacology literature has not independently characterized its mechanism.

What does the research say about Livagen?

Evidence base is essentially single-lab (Khavinson, Lezhava, and collaborators). In vitro studies on lymphocyte chromatin in elderly subjects and small Russian reports in chronic gastritis and immune senescence. No FDA-registered clinical trials and no Western RCTs.