Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Informational only. Not medical advice.INFORMATIONAL PLATFORM ONLY — NOT MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT
Head-to-head comparison of LGD-3303 and RAD-140 — mechanism, side effects, legal status, and pricing.
LGD-3303 is a non-peptide small molecule belonging to the pyrrolo[3,2-f]quinolinone class of selective androgen receptor modulators (SARMs). It has never been approved by the FDA or any regulatory agency for human use, and no human clinical trials have been conducted or registered. LGD-3303 is prohibited under WADA's S1.2 category (Other Anabolic Agents), which covers all SARMs as a class. All available data are preclinical, derived from in vitro AR binding assays and in vivo studies in castrated rats and horses.
RAD-140 (testolone) is a non-steroidal small-molecule selective androgen receptor modulator (SARM) — not a peptide — developed by Radius Health. It is NOT FDA-approved for any indication. Grey-market use for bodybuilding is associated with documented drug-induced liver injury (hepatotoxicity), testosterone suppression, and adverse cardiovascular effects. It is a WADA-prohibited substance. It is tracked in peptide-research spaces because of overlapping grey-market performance use.
LGD-3303
RAD-140
Category
Legal Status
Mechanism
Half-life
Side Effects
COA-verified vendors · trust score ≥70 required · single-vial price — bulk/bundle deals may be lower
LGD-3303
RAD-140
No pricing data yet.
Check RAD-140 prices →COA corpus from Disclosed Labs — independently tested batches only.
LGD-3303
2
COAs
99.0%
Avg purity
2
Labs
RAD-140
No COA data yet.
Submit testing data →No human data exist for LGD-3303. No completed or registered clinical trials were found on ClinicalTrials.gov, and no PubMed record of a Phase 1 or later human trial exists. In castrated Sprague-Dawley rats, LGD-3303 showed potent anabolic (levator ani muscle) agonist activity but only partial agonist activity on androgenic tissues (ventral prostate, preputial gland); tissue selectivity was maintained across both oral dosing and continuous infusion despite very different plasma exposure-time profiles (Vajda et al. 2009, PMID 19017848). In horses dosed orally at 0.05 mg/kg, eight metabolites (including hydroxylated and carboxylated forms with glucuronic acid conjugates) were tentatively identified in plasma and urine for doping-control purposes, with a monohydroxylated metabolite identified as the most sensitive analytical marker (Nilsson Broberg, Knych, Bondesson et al. 2023, PMID 37224728).
Key references
Miller et al. (2010, ACS Med Chem Lett) first described the design, synthesis, and preclinical characterization of RAD140 as a high-affinity tissue-selective AR agonist. Jayaraman et al. (2014, Endocrinology) demonstrated neuroprotection in cultured neurons and kainate-lesioned rats. LoRusso et al. (2022, Clinical Breast Cancer) reported the first-in-human Phase 1 dose-escalation in ER+/HER2- metastatic breast cancer (MTD 100 mg/day); efficacy was modest and hepatic AEs were frequent (AST 59%, ALT 46%, bilirubin 27%), and development did not progress to approval. Leung et al. (2022, Ochsner Journal) and subsequent case series document severe cholestatic drug-induced liver injury from grey-market RAD-140 use. Van Wagoner et al. (2017, JAMA) showed that only ~52% of internet-marketed SARM products contained the labeled compound, compounding grey-market risk. FDA has issued public warnings that SARMs are not safe for human consumption, and RAD-140 is banned by WADA. No FDA approval pathway is currently established.
LGD-3303 and RAD-140 are both in the Performance category and may have overlapping mechanisms. Researchers should review both profiles carefully, understand the mechanisms of action, and monitor the relevant biomarkers when combining compounds in the same class. As always, consult a licensed healthcare provider before making any decisions about combining research compounds.
This platform provides informational tools only, not medical advice. This comparison is for educational purposes only. Consult a licensed provider.
Contraindications
Lab Testing
Key references
Disclosed Labs