BPC-157

Overview

BPC-157 is a synthetic pentadecapeptide (sequence GEPPPGKPADDAGLV) derived from a fragment of body protection compound, a protein isolated from human gastric juice. It is research-only and not approved by the FDA or any major regulator for human use; almost all published evidence comes from rodent models.

Mechanism of Action

Preclinical studies suggest BPC-157 promotes angiogenesis and granulation tissue formation via upregulation of VEGFR2 signaling and activation of the FAK-paxillin pathway in tendon fibroblasts. It also modulates the nitric oxide system and interacts with dopaminergic and serotonergic pathways along the gut-brain axis. A precise receptor target has not been established.

Research Summary

Extensive rodent data from the Sikiric group and others report accelerated healing of tendon, ligament, muscle, and gastrointestinal injury, plus cytoprotective effects in models of NSAID and alcohol damage (PMID 21548867, 30915550). Preclinical tendon studies demonstrate enhanced growth hormone receptor expression in fibroblasts (PMID 25415472) and promote tendon outgrowth, cell survival, and cell migration (PMID 21030672). Published human clinical evidence is limited; an early oral formulation (PL 14736) was explored for inflammatory bowel disease but has not progressed to approval. No peer-reviewed trial validates the injectable doses (200–500 mcg) commonly used on the grey market, and pharmacokinetics and long-term safety in humans are not well characterized.

Vendors selling BPC-157

Scored vendors carrying BPC-157, ranked by trust grade. Grades are computed from indexed Certificates of Analysis. Full $/mg pricing is on the comparison page.

Prescribers who offer BPC-157

378 prescribers in our directory work with BPC-157, each confirmed from their own website. Peptides like BPC-157 require a prescription from a licensed provider.

Reported Side Effects

• Nausea (especially oral)
• Dizziness or lightheadedness
• Injection site irritation
• Headache
• Note: the human side-effect profile is not well characterized in peer-reviewed literature

Biomarkers researchers track for BPC-157

These biomarkers appear in the research literature as measures of response and safety for this compound.

Related Peptides

Research Guides

• Cheapest verified BPC-157: live prices, vendors & COA data

Compare BPC-157 with Others

Research References

• Sikiric P, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. 2011. PMID 21548867.
• Chang CH, et al. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. 2014. PMID 25415472.
• Gwyer D, et al. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. 2019. PMID 30915550.
• Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. 2011. PMID 21030672.

Frequently asked questions

Has BPC-157 been independently lab-tested?

Disclosed Labs has collected 338 Certificates of Analysis (COA) for BPC-157 from 16 independent testing labs. 51 vendors have submitted material for testing. Products average 99.3% tested purity across the corpus. Full testing data is available at https://www.disclosedlabs.com/peptides/bpc-157/testing.

What is the average purity of BPC-157 on the market?

Based on 338 COAs analyzed by Disclosed Labs, BPC-157 products average 99.3% (±1.5%) tested purity. Individual vendor results vary; see per-vendor COA data at https://www.disclosedlabs.com/peptides/bpc-157/coas.

Which labs have tested BPC-157?

Independent labs that have tested BPC-157 include: ILS Labs (Grade B), Ethos Analytics (Grade C). Full lab credibility grades and profiles are at https://www.disclosedlabs.com/labs.

Where can researchers source BPC-157?

8 vendors with Disclosed Labs trust grades currently list BPC-157, including Glacier Aminos, Voltera Sciences, Crush Research. Compare live prices and lab-verified COAs at https://www.disclosedlabs.com/prices/bpc-157.

Which prescribers offer BPC-157 with a prescription?

378 prescribers in the Disclosed Labs directory work with BPC-157, each confirmed from their own website. BPC-157 requires a prescription from a licensed provider. Browse them at https://www.disclosedlabs.com/prescribers?peptide=BPC-157.

How does BPC-157 work?

Preclinical studies suggest BPC-157 promotes angiogenesis and granulation tissue formation via upregulation of VEGFR2 signaling and activation of the FAK-paxillin pathway in tendon fibroblasts. It also modulates the nitric oxide system and interacts with dopaminergic and serotonergic pathways along the gut-brain axis. A precise receptor target has not been established.

What does the research say about BPC-157?

Extensive rodent data from the Sikiric group and others report accelerated healing of tendon, ligament, muscle, and gastrointestinal injury, plus cytoprotective effects in models of NSAID and alcohol damage (PMID 21548867, 30915550). Preclinical tendon studies demonstrate enhanced growth hormone receptor expression in fibroblasts (PMID 25415472) and promote tendon outgrowth, cell survival, and cell migration (PMID 21030672). Published human clinical evidence is limited; an early oral formulation (PL 14736) was explored for inflammatory bowel disease but has not progressed to approval. No peer-reviewed trial validates the injectable doses (200–500 mcg) commonly used on the grey market, and pharmacokinetics and long-term safety in humans are not well characterized.