AHK-Cu

Overview

AHK-Cu is a copper-binding tripeptide (Ala-His-Lys-Cu) structurally related to GHK-Cu, studied in dermatological research for its role in extracellular matrix remodeling and hair follicle signaling.

Mechanism of Action

AHK-Cu chelates copper(II) through histidine and lysine residues, forming a stable peptide-metal complex. It upregulates collagen I, collagen III, and VEGF expression in dermal fibroblasts and papilla cells, potentially supporting dermal remodeling and hair follicle vascularization. Also influences MMP activity and glycosaminoglycan synthesis.

Research Summary

Pyo et al. (Archives of Pharmacal Research, 2007) reported that AHK-Cu stimulated elongation of human hair follicles ex vivo, promoted proliferation of dermal papilla cells, and increased VEGF secretion while reducing TGF-beta1 in cultured fibroblasts. Evidence is preclinical only; no controlled clinical trials have been published.

Dosing Information

Reported Side Effects

• Limited human safety data
• Mild skin irritation or redness at topical application site
• Contact dermatitis in copper-sensitive individuals
• Transient itching or warmth at application site

Research References

• The effect of tripeptide-copper complex on human hair growth in vitro (2007)