Hormone Optimization Stack

Gonadorelin (GnRH pulse), Kisspeptin-10 (upstream GnRH trigger), and Enclomiphene (estrogen receptor modulation) target the hypothalamic-pituitary-gonadal axis at three different levels. Often used in PCT (post-cycle therapy) research contexts or for studying endogenous testosterone restoration.

Hormone3 compounds12 vendors comparedStack from $217.99

Compounds in this stack

Gonadorelin

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH) used to maintain fertility and endogenous testosterone production during TRT. It is commonly co-prescribed with testosterone replacement therapy to prevent testicular atrophy and preserve HPG axis function.

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Role: GnRH agonist. Directly pulses the pituitary to release LH and FSH. The standard research tool for maintaining gonadotropin signaling.

100mcgSubQ2x/week

1.Peptidology11mg

$6.18/mgBuy

2.Peptide Tech2mg

$14.99/mgBuy

3.Soma Peptides2mg

$29.50/mgBuy

Gonadorelin (GnRH) for the preservation of fertility in men … (2019)Maintaining fertility during testosterone replacement therap… (2015)Pulsatile GnRH therapy for hypothalamic amenorrhea and male … (2010)

Kisspeptin-10

Kisspeptin-10 is a truncated fragment of the kisspeptin neuropeptide that plays a central role in reproductive hormone signaling. It is a potent stimulator of GnRH release and is studied for its role in fertility, puberty, and hypogonadism.

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Role: Upstream GnRH trigger. Activates kisspeptin receptors on GnRH neurons in the hypothalamus, stimulating endogenous GnRH pulsatility.

100mcgSubQdaily

1.Simple Peptide10mg

$4.50/mgBuy

2.Hydro Research Peptides10mg

$4.50/mgBuy

Enclomiphene

Enclomiphene is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM) that stimulates endogenous testosterone production. While not a peptide, it is widely tracked in the peptide and TRT community as an alternative or adjunct to testosterone replacement therapy.

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Role: Selective estrogen receptor modulator (SERM). Blocks hypothalamic estrogen feedback, disinhibiting GnRH/LH secretion. Oral, non-peptide compound commonly paired with peptide protocols.

12.5mgOraldaily

1.Nova Peptides12.5mg

$8.40/mgBuy

Enclomiphene citrate stimulates testosterone production whil… (2013)Oral enclomiphene citrate versus injectable testosterone for… (2016)

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For research purposes only. Not medical advice, diagnosis, or treatment. Consult a licensed provider before making any decisions based on this information.